A Research Study On Breast Cancer - 1308 Words

Introduction Breast Cancer is on the fore-front of modern tumor research and scientists are continually seeking for new ways to treat and prevent cancer progression. Current treatments by hormone-dependent drugs like Tamoxifen and Raloxifene focus on estrogen receptor inhibition in mammary and endometrial cell lines. This group of drugs are known as selective-estrogen receptor modulators or SERMS, which are effective in estrogen-receptor positive (ER+) and hormone-estrogen receptor 2 positive (HER2+) breast cancers . Currently , researchers have turned their attention to retinoids – materials similar to vitamin A, which control cell proliferation and differentiation, apoptosis, and gene suppression in both normal and cancerous epithelial tissues. Specifically, fenretinide, a synthetic retinoid, is of particular interest for treating epithelial breast cancer after yielding positive results in inducing apoptosis in in vitro, in vivo, and clinical trials. Fenretinide’s exact function s in the cell for chemo-preventative use are still being discovered, such as its supposed relationship with the nuclear retinoid receptors RARÉ £ and RXR ÃŽ ², which control cell growth and apoptosis, and its effect on insulin-growth factor (IGF) receptors, which are high risk factors for breast cancer. Fenretinide has been discovered inducing cell death by other novel means through receptor-independent mechanisms . Combination therapy of fenretinide and Tamoxifen together has shown greater effect onShow MoreRelatedA Research Study On Breast Cancer2138 Words   |  9 Pages Breast Cancer accounts for more than 20 percent of cancer in women, and is the primary cause of cancer death among women globally.1 Despite extensive scientific research on the disease, the outlook on a cure arguably remains poor. While some breast cancer survivors and women at high risk remain hopeful that soy intake will reduce the risk or even cure cancer, the recommendations are conflicting. For decades, the relationship between soy foods, supplements, phytoestrogen intake and cancer hasRead MoreA Research Study On Breast Cancer981 Words   |  4 PagesIn this case study we have Sarah a forty-two-year-old woman who has breast cancer which has metastasized to her lungs. Despite having had multiple tumors removed the cancer has returned. Sarah’s oncologist, Greg, recommends that she take part in a double blind experimental drug trial in an effort to slow the occurrence of more tumors. Greg explains that the risks of the drug are not entirely known; the drug won’ t cure her cancer but may slow its progression, it may leave her extremely fatiguedRead MoreA Research Study On Breast Cancer1702 Words   |  7 PagesIntroduction Breast cancer is one of the leading causes of high mortality and morbidity in women population worldwide. Up to date, no effective breast cancer treatment has been developed and this has motivated academic scientists for the quest for alternative drugs and the discovery of drug targets. Increasing evidence suggests that carotenoids, which are micronutrients in fruit and vegetables, reduce breast cancer risk [1]. Previous findings suggest a protective role of ÃŽ ±-carotene, ÃŽ ²-carotene,Read MoreBreat Cancer Screening Essay1514 Words   |  7 PagesBREAST CANCER SCREENING DR. DANA MORTEZ ARLECIA PURVIS JULY 17, 2011 Current research shows mammograms are stronger than in the past. In a recent study it has confirmed that mammograms benefit for women in their forties and fifties. Women feel confident about the benefits that are associated with a regular mammograms for finding cancer early. However, mammograms can have their limitations. A mammogram will miss some cancers, and it sometimes can leadRead MoreA Short Note On Soy Products Good Or Bad For Cancer?1100 Words   |  5 PagesPeBenito 12/5/14 Bio 100 Section-09 Lynne Dowdy Soy Products Good or Bad for Cancer? Cancer is a disease that has been an ongoing controversy on what can help to prevent getting it. Cancer is when cells are dividing at an uncontrollable rate. Cancer is developed when cancer cells go into lymph nodes and also when they take over the blood vessels, lymph nodes are when there is swelling the the lymphatic system. With the cancer there is swelling which is called a tumor. Tumor is when there is swellingRead MoreThe Issue Of Breast Cancer830 Words   |  4 PagesThe issue of breast cancer affecting many individuals is a growing one. At the present time period it is now found that one in every eight women will be told they have breast cancer (â€Å"National Breast Cancer Foundation†, 2012). Therefore there is a significant amount of research going into this area. In addition, to the large amount of women and smaller amount of men who will be potentially diagnosed with breast cancer has become a global burden because those with metastatic cancer will eventuallyRea d MoreThe Survival Rates Of Breast Cancer1373 Words   |  6 Pages Breast Cancer is the most common misfortune in women and second leading cause of death by cancer. Today, woman with breast cancer have a 90% chance of surviving for five years post-diagnosis. However, African American women have a national survival rate of 79%. Socioeconomic barriers and lack of access to health services have crippled African American women in breast cancer advancements. Studies have show that African American women tend to be diagnosed with a higher-stage of cancer because ofRead MoreThe Importance Of Breast Cancer Treatment934 Words   |  4 PagesBreast cancer treatment depends on many factors such as the location of the cancer, the size, if it’s spread and the patient’s general health. Also, treatment currently includes surgery, chemotherapy, radiotherapy, hormonal therapy and targeted cancer drugs (Cancer Research UK, 2017a). Further, surgery includes lumpectomy which removes just the cancerous area in an attempt to keep the majority of the breas t tissue and has a much shorter recovery time and mastectomy which removes the entirety of theRead MoreA Brief Note On The North Fork Of Long Island1726 Words   |  7 Pagesweeds, these commodities would be much harder to come by. Chemicals such as PCB’s, PHA’s, and the now banned DDT were all once used on these fertile farmlands of Long Island and since then may be a direct factor to the rise in cancer rates on Long Island, especially breast cancer. In the agricultural industry, one of the most common ways to treat crops is by a fogging method. With this method, a large factor goes through the crops with tanks of whatever chemical pesticide or fungicide they may be usingRead MoreBreast Cancer : A Common Malignancy1204 Words   |  5 PagesBreast cancer is the most common malignancy in the UK, accounting for 15% of all diagnosed cancers, affecting around 50,000 women and 350 men, leading to just under 12,000 deaths in 11/12.1,2 The risk of getting breast cancer is linked to increased age, gender genetics (BRCA 1 BRCA 2 gene mutations). Lifestyle factors that also increase the incidence of breast cancer (around 27% each year) are; Oestrogen exposure, being overweight/obese, high alcohol intake, tobacco smoke, oral contraceptives